Compounded · prescription only
Semaglutide + B12
The GLP-1 medicine with the longest track record, at our lowest monthly price. Prescribed and adjusted by a U.S.-licensed clinician.
- Type
- GLP-1
- How it's taken
- Injection under the skin
- How often
- Once a week
- Dose range
- 0.25–2.4 mg
Pick your plan.
Longer plans cost less per month. Same price at every dose.
1. Choose a medication
2. Choose how you take it
Semaglutide + B12. A once-weekly GLP-1 injection, compounded with vitamin B12. A well-studied place to start, at a lower monthly cost.
Compounded for you by Perfect RX, a state-licensed pharmacy, on a clinician's prescription. Not FDA-approved and not the same as any brand-name product.
3. Choose how often you pay
- Online review by a U.S.-licensed clinician
- Medication and supplies, shipped monthly
- Dose adjustments as you go, same price at every dose
- Unlimited messaging with your care team
- Free, discreet shipping
- Pause or cancel anytime
About 5 minutes. A clinician reviews everything before anything ships.
How it works in your body
Turning up the “I’m full” signal.
GLP-1 is a hormone your gut releases after a meal. It signals fullness to your brain, slows how fast your stomach empties and helps regulate blood sugar.
Semaglutide is a long-acting version of that signal. One injection a week keeps it steady, so many people find they eat less without the constant fight with hunger.
What to expect
Week by week, not overnight.
- Week 1
You start on a low dose (usually 0.25 mg) to give your body time to adjust.
- Weeks 2–8
Nausea, fullness or constipation are common early on and after a dose increase. Your care team helps you through it.
- Months 3–6
Your clinician steps the dose up at check-ins, usually every four weeks, toward the dose that works best for you.
- Month 6 and on
Together you decide how to hold your progress: maintain, adjust or taper gradually.
Everyone responds differently. Your clinician sets the pace with you.
The research
What the trials found.
average weight loss at 68 weeks on brand-name semaglutide 2.4 mg, vs 2.4% on placebo, in 1,961 adults.
lower risk of major heart events with brand-name semaglutide 2.4 mg in adults with heart disease and overweight, vs placebo.
Results are from trials of FDA-approved brand-name medicines, used with diet and activity changes. Compounded semaglutide was not studied in these trials. Vitamin B12 has not been tested as a weight-loss ingredient. Individual results vary.
Semaglutide questions
Before you start.
A small injection under the skin, once a week on the same day. Your kit includes supplies and instructions, and your care team is a message away.
Both work on appetite. Tirzepatide acts on two hormone receptors and led to more weight loss in a head-to-head trial of the brand-name versions. Semaglutide has the longer track record and costs less. Your clinician will help you decide.
No. Your plan price stays the same at every dose.
No. Compounded semaglutide is prepared by a state-licensed pharmacy for you individually, on a prescription. It is not FDA-approved and is not a generic version of any brand-name product.
Important Safety Information
Warning: possible thyroid tumors, including cancer. In studies in rodents, tirzepatide and semaglutide caused thyroid C-cell tumors. It is not known whether they cause these tumors in people. Do not use GLP-1 medication if you or a family member has ever had medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your clinician about a lump or swelling in your neck, trouble swallowing, hoarseness or shortness of breath.
Do not use if you are pregnant, planning to become pregnant or breastfeeding, or if you have had a serious allergic reaction to tirzepatide, semaglutide or any ingredient.
Serious side effects can include pancreatitis, gallbladder problems, low blood sugar, kidney problems, serious allergic reactions, vision changes in people with diabetes, and mood changes. Common side effects include nausea, diarrhea, vomiting and constipation. Compounded medications are not FDA-approved. Read the full Important Safety Information.
Ready when you are.
Answer a few questions online. A licensed clinician reviews them and, if it's right for you, your treatment ships to your door.
See if you qualify